(S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate

Base Information

Chemical Name:(S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate
CAS No.:1435955-08-0
Molecular Formula:C₂₄H₂₃N₇O₃S
Molecular Weight:489.558
Hs Code.:

Synonyms:(S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate

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Chemical Property of (S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate

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Technology Process of (S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate

There total 6 articles about (S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₅NO₄

: 1435953-84-6
7-[(2S)-2-methylpiperazin-1-yl]thiazolo[5,4-d]pyrimidin-5-amine hydrochloride

: 1435955-08-0
(S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 60 ℃; for 3h;

Reference yield:

: 720-98-9
4-benzoyloxy-aniline

: 1435953-84-6
7-[(2S)-2-methylpiperazin-1-yl]thiazolo[5,4-d]pyrimidin-5-amine hydrochloride

: 1885-14-9
phenyl chloroformate

: 1435955-08-0
(S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate

Guidance literature:: 4-benzoyloxy-aniline; phenyl chloroformate; With pyridine; In tetrahydrofuran; at 0 ℃; for 2h;

7-[(2S)-2-methylpiperazin-1-yl]thiazolo[5,4-d]pyrimidin-5-amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 60 ℃; for 3h;

Reference yield:

: 171887-03-9
N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide

: 1435955-08-0
(S)-4-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-3-methylpiperazine-1-carboxamido]-phenyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / tetrahydrofuran / 0.5 h / 65 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.75 h / 120 °C / Microwave irradiation

3: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 3 h / 60 °C

With Lawessons reagent; hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;