pteroyl-lys

Base Information

• Chemical Name: pteroyl-lys
• CAS No.: 55668-03-6
• Molecular Formula: C₂₀H₂₄N₈O₄
• Molecular Weight: 440.462
• Mol file: 55668-03-6.mol

Synonyms:pteroyl-lys

Chemical Property of pteroyl-lys

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pteroyl-lys

There total 7 articles about pteroyl-lys which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C25H32N8O6 (16286-44-5) → pteroyl-lys (55668-03-6)

Guidance literature:

With pyridine; trifluoroacetic acid; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/j.bmcl.2011.02.014

Reference yield:

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid (2418-95-3) → pteroyl-lys (55668-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 7 h / 20 °C

2: pyridine; trifluoroacetic acid / N,N-dimethyl-formamide / 0 °C

With pyridine; trifluoroacetic acid; N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.014

Reference yield:

folate (59-30-3) → pteroyl-lys (55668-03-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 10 h / 0 - 20 °C

2.1: tetrahydrofuran / 5 h / 20 °C / Cooling with ice

3.1: hydrazine / dimethyl sulfoxide / 12 h / 20 °C

4.1: potassium thioacyanate; trifluoroacetic acid / -10 - 0 °C

4.2: 5 h / 20 °C

5.1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 7 h / 20 °C

6.1: pyridine; trifluoroacetic acid / N,N-dimethyl-formamide / 0 °C

With pyridine; potassium thioacyanate; trifluoroacetic acid; hydrazine; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.014

upstream raw materials:

C₂₅H₃₂N₈O₆

C₁₄H₁₃N₇O₂

pteroyl hydrazide

pteroyl azide

Downstream raw materials:

pteroyl-lys-HYNIC

C₆₉H₈₃N₉O₂₀

C₂₁H₂₃N₈O₄S₂^(1-)*K⁽¹⁺⁾