3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Base Information

Chemical Name:3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea
CAS No.:1617504-99-0
Molecular Formula:C₃₁H₂₈F₃N₃O₃
Molecular Weight:547.577
Hs Code.:

Synonyms:3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Suppliers and Price of 3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

There total 6 articles about 3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1555701-59-1
3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

: 98-80-6
phenylboronic acid

: 1617504-99-0
3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In Dimethyl ether; at 100 ℃; for 50h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm5006226

Reference yield:

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

: 1617504-99-0
3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; ammonium chloride / 1 h / 20 °C / Inert atmosphere

2: dichloromethane / 16 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / Dimethyl ether / 50 h / 100 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; ammonium chloride; zinc; In Dimethyl ether; dichloromethane; 3: |Suzuki Coupling;
DOI:10.1021/jm5006226

Reference yield:

: 1555699-78-9
2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)aniline

: 1617504-99-0
3-[2-(7-methoxy-3,3-dimethyl-4-phenyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 16 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / Dimethyl ether / 50 h / 100 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In Dimethyl ether; dichloromethane; 2: |Suzuki Coupling;
DOI:10.1021/jm5006226