(2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-6-O-Methyl-guanosine

Base Information

• Chemical Name: (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-6-O-Methyl-guanosine
• CAS No.: 1199809-27-2
• Molecular Formula: C₁₂H₁₆FN₅O₄
• Molecular Weight: 313.289
• Mol file: 1199809-27-2.mol

Synonyms:(2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol

Chemical Property of (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-6-O-Methyl-guanosine

Chemical Property:

• Density: 1.77

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-6-O-Methyl-guanosine

There total 9 articles about (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-6-O-Methyl-guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate (1199809-26-1) + sodium methylate (124-41-4) → (2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol (1199809-27-2)

Guidance literature:

In methanol; at 50 ℃; for 3.5h; Inert atmosphere;

Reference yield: 93.0%

C25H25ClFN5O3 + sodium methylate (124-41-4) → (2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol (1199809-27-2)

Guidance literature:

With methanol; at 20 ℃; for 24h;

Reference yield: 92.0%

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-(((4-chlorobenzoyl)oxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-chlorobenzoate (1294481-82-5) + sodium methylate (124-41-4) → (2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol (1199809-27-2)

Guidance literature:

In methanol; at 20 ℃; for 6.33h; Inert atmosphere; Cooling with ice;

upstream raw materials:

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate

sodium methylate

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate)

Downstream raw materials:

(S)-2-{(S)-[(1R,4R,5R)-5-(2-amino-6-methoxy-purin-9-yl)-4-(R)-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-ylmethoxy]phenoxy-phosphorylamino}propionic acid isopropyl ester

C₂₄H₃₂FN₆O₈P

(2S)isopropyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

C₂₄H₃₁BrFN₆O₈P