ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

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Chemical Name:ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate
CAS No.:1264296-70-9
Molecular Formula:C₂₆H₂₂BrF₄N₃O₂
Molecular Weight:564.377
Hs Code.:

Synonyms:ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

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Chemical Property of ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

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Technology Process of ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

There total 6 articles about ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263940-78-8
ethyl 3-(3-fluorophenyl)-2-methyl-2-(2-methyl-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

: 1264296-70-9
ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 60 ℃; for 12h;

Reference yield:

: 1264296-25-4
3-methyl-3-(methylsulfonyl)-4-phenylbutan-2-one

: 1264296-70-9
ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 12 h / 100 °C

2: trifluoroacetic acid / ethanol / 12 h / 80 °C

3: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 60 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trifluoroacetic acid; In tetrachloromethane; ethanol;

Reference yield:

: 1264296-30-1,1221133-66-9
3-methyl-4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine

: 1264296-70-9
ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / ethanol / 12 h / 80 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 60 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trifluoroacetic acid; In tetrachloromethane; ethanol;