tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate

Base Information

• Chemical Name: tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate
• CAS No.: 189808-70-6
• Molecular Formula: C₁₂H₂₅NO₅
• Molecular Weight: 263.334

Synonyms:tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate

Chemical Property of tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate

Chemical Property:

• Boiling Point: 343.4±27.0 °C(Predicted)
• Density: 1.041±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

H2N-PEG3-CH2COOtBu min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Amino-PEG3-CH2CO2-t-butyl ester is a PEG molecule containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group (t-Boc) can be deprotected under acidic conditions.

Technology Process of tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate

There total 17 articles about tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-[2-(2-(2-azidoethoxy)ethoxy)ethoxy]acetate (172531-36-1) → tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate (189808-70-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3.5h;

DOI:10.1002/anie.200502570

Reference yield: 87.0%

tert-butyl 2-(2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)ethoxy)ethoxy)acetate → tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate (189808-70-6)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 2h;

Reference yield: 75.0%

tert-butyl 2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)acetate → tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate (189808-70-6)

Guidance literature:

tert-butyl 2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)acetate; With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 18h; Inert atmosphere;

With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 18h;

DOI:10.1021/acsmedchemlett.1c00368

upstream raw materials:

tert-butyl 2-[2-(2-(2-azidoethoxy)ethoxy)ethoxy]acetate

bromoacetic acid tert-butyl ester

tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

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