cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide

Base Information

• Chemical Name: cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide
• CAS No.: 152912-11-3
• Molecular Formula: C₁₇H₁₅Cl₂NO₂
• Molecular Weight: 336.218
• Mol file: 152912-11-3.mol

Synonyms:cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide

Chemical Property of cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide

There total 2 articles about cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol (74067-45-1) + cyclopropanecarboxylic acid chloride (4023-34-1) → cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide (152912-11-3)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0968-0896(01)00290-5

Reference yield:

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide (152912-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol

2: 84 percent / NaHCO₃ / CH₂Cl₂ / 0.5 h / 20 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; In ethanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00290-5

Reference yield: 78.0%

cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide (152912-11-3) → [5-chloro-2-(cyclopropylmethyl-amino)-phenyl]-(2-chloro-phenyl)-methanol (152910-46-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1016/S0968-0896(01)00290-5

upstream raw materials:

2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

cyclopropanecarboxylic acid chloride

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

Downstream raw materials:

[5-chloro-2-(cyclopropylmethyl-amino)-phenyl]-(2-chloro-phenyl)-methanol

(E)-3-({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-cyclopropylmethyl-carbamoyl)-acrylic acid ethyl ester