(2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol

Base Information

Chemical Name:(2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol
CAS No.:214773-44-1
Molecular Formula:C₂₆H₄₀O₃SeSi
Molecular Weight:507.647
Hs Code.:

Synonyms:(2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol

Chemical Property:

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Technology Process of (2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol

There total 6 articles about (2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1666-13-3
diphenyl diselenide

: 214773-28-1
{3-[(2S,3R)-3-((S)-1-Benzyloxy-ethyl)-oxiranyl]-propoxy}-tert-butyl-dimethyl-silane

: 214773-44-1
(2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 2h; Heating;
DOI:10.1002/jhet.5570350414

Reference yield:

: 100-39-0
benzyl bromide

: 214773-44-1
(2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, from 0 deg C to RT, 15 min, 2.) THF, RT, 3 h

2: 88 percent / NaBH₄ / ethanol / 2 h / Heating

With sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; sodium hydride; In ethanol;
DOI:10.1002/jhet.5570350414

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 214773-44-1
(2S,3R,4R)-2-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-heptan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / imidazole / CH₂Cl₂ / 14 h / Ambient temperature

2: 90 percent / m-CPBA / CH₂Cl₂ / 2 h / 0 °C

3: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, from 0 deg C to RT, 15 min, 2.) THF, RT, 3 h

4: 88 percent / NaBH₄ / ethanol / 2 h / Heating

With 1H-imidazole; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;
DOI:10.1002/jhet.5570350414