C₂₅H₂₇FN₄O

Base Information

Chemical Name:C₂₅H₂₇FN₄O
CAS No.:1300858-82-5
Molecular Formula:C₂₅H₂₇FN₄O
Molecular Weight:418.514
Hs Code.:

C<sub>25</sub>H<sub>27</sub>FN<sub>4</sub>O

Synonyms:C₂₅H₂₇FN₄O

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Chemical Property of C₂₅H₂₇FN₄O

Chemical Property:

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Technology Process of C₂₅H₂₇FN₄O

There total 7 articles about C₂₅H₂₇FN₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300695-94-6
phenylmethyl [(4-{(2S,4R)-1-acetyl-4-[(5-fluoro-2-pyridinyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}phenyl)methyl]methylcarbamate

: 1300858-82-5
C₂₅H₂₇FN₄O

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 17h;

Reference yield:

: 699-03-6
N-methyl-4-bromobenzylamine

: 1300858-82-5
C₂₅H₂₇FN₄O

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 1.25 h / Inert atmosphere; Reflux

4: methanol; acetyl chloride / 3 h / 20 °C

5: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane; toluene / 22 h / 110 °C

6: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C

With methanol; hydrogen; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; acetyl chloride; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1300695-44-6
tert-butyl ((2S,4R)-1-acetyl-6-bromo-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate

: 1300858-82-5
C₂₅H₂₇FN₄O

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 1.25 h / Inert atmosphere; Reflux

2: methanol; acetyl chloride / 3 h / 20 °C

3: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane; toluene / 22 h / 110 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C

With methanol; hydrogen; potassium carbonate; acetyl chloride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; ethanol; toluene;