1H-Imidazole, 1-(2-phenoxyethyl)-

Base Information

• Chemical Name: 1H-Imidazole, 1-(2-phenoxyethyl)-
• CAS No.: 30170-83-3
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.229
• UNII: NG9HS65MAS
• ChEMBL ID: CHEMBL284827
• Pharos Ligand ID: FHJS6R6LRK5P
• Mol file: 30170-83-3.mol

Synonyms:1-(2-Phenoxyethyl)imidazole;CHEMBL284827;1H-Imidazole, 1-(2-phenoxyethyl)-;1-(2-Phenoxy-ethyl)-1H-imidazole;30170-83-3;NG9HS65MAS;SCHEMBL10370478;Imidazole, 1-(2-phenoxyethyl)-;INUSBZKZIYQSRM-UHFFFAOYSA-N;1-(2-Phenoxyethyl)-1H-imidazole;BDBM50025988;AKOS002677376;PD178858

Chemical Property of 1H-Imidazole, 1-(2-phenoxyethyl)-

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 188.094963011
• Heavy Atom Count: 14
• Complexity: 157

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCCN2C=CN=C2

Technology Process of 1H-Imidazole, 1-(2-phenoxyethyl)-

There total 4 articles about 1H-Imidazole, 1-(2-phenoxyethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-imidazole (288-32-4) + phenoxyethyl bromide (589-10-6) → 1-(2-phenoxyethyl)-1H-imidazole (30170-83-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1211/146080899128735225

Reference yield:

1H-imidazole (288-32-4) + 2-chloroethoxybenzene (622-86-6) → 1-(2-phenoxyethyl)-1H-imidazole (30170-83-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 100 deg C, 10 min, 2.) DMF, heating, 5.5 h;

DOI:10.1021/jm00148a009

Reference yield:

phenol (108-95-2,27073-41-2) → 1-(2-phenoxyethyl)-1H-imidazole (30170-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / butan-2-one / 48 h / Heating

2: NaH / tetrahydrofuran / 20 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; butanone;

DOI:10.1211/146080899128735225

upstream raw materials:

1H-imidazole

2-chloroethoxybenzene

phenoxyethyl bromide

phenol

Downstream raw materials:

4-<2-(1H-imidazol-1-yl)ethoxy>benzenesulfonamide