C₃₀H₄₀N₄O₅S

Base Information

• Chemical Name: C₃₀H₄₀N₄O₅S
• CAS No.: 1367553-87-4
• Molecular Formula: C₃₀H₄₀N₄O₅S
• Molecular Weight: 568.737
• Mol file: 1367553-87-4.mol

Synonyms:C₃₀H₄₀N₄O₅S

Chemical Property of C₃₀H₄₀N₄O₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₄₀N₄O₅S

There total 12 articles about C₃₀H₄₀N₄O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(2S,3S,4R)-1-boc-4-hydroxy-3-methylproline (1367552-70-2) + 2-(2-chloro-1-isopropyl-1H-benzo[d]imidazol-4-yl)-4-cyclohexylthiazole (1283180-95-9) → C30H40N4O5S (1367553-87-4)

Guidance literature:

(2S,3S,4R)-1-boc-4-hydroxy-3-methylproline; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

2-(2-chloro-1-isopropyl-1H-benzo[d]imidazol-4-yl)-4-cyclohexylthiazole; In dimethyl sulfoxide; for 2h;

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) → C30H40N4O5S (1367553-87-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 1H-imidazole / dichloromethane / 0 °C

2.1: tert-butylhypochlorite / diethyl ether / 0.5 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / -10 - 40 °C

4.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.75 h / -50 - -25 °C / Inert atmosphere

4.2: 0.75 h / -50 - -40 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / -50 - -25 °C / 2068.65 Torr

6.1: tert-butylhypochlorite / diethyl ether / 0.33 h / 0 °C

7.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 5 h / -40 - 20 °C

8.1: sodium carbonate / water / 1.25 h / 20 °C

9.1: lithium hydroxide / water; methanol / 20 °C

9.2: pH 2

10.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C

10.2: 2 h

With 1H-imidazole; 2,6-dimethylpyridine; copper(I) bromide dimethylsulfide complex; tert-butylhypochlorite; potassium tert-butylate; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate (117460-96-5) → C30H40N4O5S (1367553-87-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sode de l'acide trichloroisocyanurique / toluene; water / 0 °C

2.1: triethylamine / toluene / 1 h / 0 - 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / -10 - 40 °C

4.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.75 h / -50 - -25 °C / Inert atmosphere

4.2: 0.75 h / -50 - -40 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / -50 - -25 °C / 2068.65 Torr

6.1: tert-butylhypochlorite / diethyl ether / 0.33 h / 0 °C

7.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 5 h / -40 - 20 °C

8.1: sodium carbonate / water / 1.25 h / 20 °C

9.1: lithium hydroxide / water; methanol / 20 °C

9.2: pH 2

10.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C

10.2: 2 h

With 2,6-dimethylpyridine; copper(I) bromide dimethylsulfide complex; tert-butylhypochlorite; potassium tert-butylate; hydrogen; sodium tris(acetoxy)borohydride; sode de l'acide trichloroisocyanurique; sodium carbonate; acetic acid; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene;

upstream raw materials:

L-4-hydroxyproline methyl ester hydrochloride

di-tert-butyl dicarbonate

methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate

(R)-methyl 3-((tert-butyldimethylsilyl)oxy)-3,4-dihydro-2H-pyrrole-5-carboxylate