tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate
CAS No.:1352246-53-7
Molecular Formula:C₃₁H₃₄ClF₃N₄O₃
Molecular Weight:603.084
Hs Code.:

tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

Synonyms:tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

There total 4 articles about tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862282-35-7
(3S,4R)-1-(tert-butoxycarbonyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid

: 4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidine trifluoroacetate

: 1352246-53-7
tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl acetamide; at 20 ℃;

Reference yield:

: 175135-74-7
(3-chloro-4-fluorophenyl)hydrazine hydrochloride

: 1352246-53-7
tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 16 h / 20 °C

2: dichloromethane / 3 h / 20 °C

3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl acetamide / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 419571-68-9
4-(3-oxo-butyrl)-piperidine-1-carboxylic acid tert-butyl ester

: 1352246-53-7
tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 16 h / 20 °C

2: dichloromethane / 3 h / 20 °C

3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl acetamide / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide;