[4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate

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Chemical Name:[4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate
CAS No.:1352245-04-5
Molecular Formula:C₂HF₃O₂*C₂₆H₂₆ClF₃N₄O
Molecular Weight:616.991
Hs Code.:

Synonyms:[4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate

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Chemical Property of [4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate

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Technology Process of [4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate

There total 4 articles about [4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352246-53-7
tert-butyl (3S,4R)-3-({4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidin-1-yl}carbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1352245-04-5
[4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 175135-74-7
(3-chloro-4-fluorophenyl)hydrazine hydrochloride

: 1352245-04-5
[4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol / 16 h / 20 °C

2: dichloromethane / 3 h / 20 °C

3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl acetamide / 20 °C

4: dichloromethane / 6 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 1352246-32-2
tert-butyl 4-[1-(3-chloro-4-fluorophenyl)-3-methyl-1H-pyrazol-5-yl]piperidine-1-carboxylate

: 1352245-04-5
[4-[2-(3-chloro-4-fluoro-phenyl)-5-methyl-pyrazol-3-yl]-1-piperidyl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 3 h / 20 °C

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl acetamide / 20 °C

3: dichloromethane / 6 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl acetamide;