[(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

Base Information

Chemical Name:[(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester
CAS No.:205868-34-4
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:[(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

Suppliers and Price of [(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

There total 9 articles about [(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 75-16-1
methylmagnesium bromide

: 205868-33-3
((4R)-formyl-(2R)-phenyl-(6R)-vinyl-[1,3]dioxane-(5S)-yl)methylcarbamic acid methyl ester

: 205868-34-4
[(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

Guidance literature:: In diethyl ether; for 6h; Ambient temperature;
DOI:10.1080/07328309808002322

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 205868-34-4
[(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / p-TsOH / CH₂Cl₂ / 14 h / Ambient temperature

2: 96 percent / I₂, aq. NaHCO₃ / acetone / 6 h / Ambient temperature

3: 93 percent / diethyl ether / 6 h / Ambient temperature

With iodine; sodium hydrogencarbonate; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; acetone;
DOI:10.1080/07328309808002322

Reference yield:

: [(3aR,5S,6S,6aR)-5-(2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-methyl-amine

: 205868-34-4
[(2R,4R,5S,6R)-4-(1-Hydroxy-ethyl)-2-phenyl-6-vinyl-[1,3]dioxan-5-yl]-methyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / K₂CO₃ / acetone / 3 h / Heating

2: 70 percent / CH₃CO₂H, H₂O / methanol / 14 h / 55 °C

3: 98 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

4: 97 percent / NaI / butan-2-one / 15 h / 70 °C

5: 98 percent / ZnCl₂ / CH₂Cl₂ / 12 h / Ambient temperature

6: 94 percent / p-TsOH / CH₂Cl₂ / 14 h / Ambient temperature

7: 96 percent / I₂, aq. NaHCO₃ / acetone / 6 h / Ambient temperature

8: 93 percent / diethyl ether / 6 h / Ambient temperature

With water; iodine; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; sodium iodide; zinc(II) chloride; In methanol; diethyl ether; dichloromethane; acetone; butanone;
DOI:10.1080/07328309808002322