5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid

Base Information

• Chemical Name: 5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid
• CAS No.: 1337920-25-8
• Molecular Formula: C₂₃H₂₂N₂O₄
• Molecular Weight: 390.439
• Mol file: 1337920-25-8.mol

Synonyms:5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid

Chemical Property of 5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid

There total 1 articles about 5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

glutaric anhydride, (108-55-4) + N-(3-aminopropionyl)-5,6-dihydro-11,12-didehydrodibenzo[b,f]azocine (1255942-06-3) → 5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid (1337920-25-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

Reference yield: 36.0%

5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid (1337920-25-8) + 4-((S)-80-((S)-2-amino-3-methylbutanamido)-74-oxo-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71-tetracosaoxa-75-azahenoctacontanamido)benzyl 4-((2R,3R)-3-((S)-1-((3S,10R,16S,E)-10-(3-chloro-4-methoxybenzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diazacyclohexadec-13-en-16-yl)ethyl)oxiran-2-yl)benzylcarbamate → DBCO-glutaryl-Val-PEG24Ly5-PABA-C52 benzylic amine

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

5-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-5-oxopentanoic acid (1337920-25-8) → C59H58N8O6 (1572187-29-1)

Guidance literature:

Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide; dmap / N,N-dimethyl-formamide / 12 h / 20 °C

2: methanol / 25 °C

3: 0.03 h / Irradiation

4: methanol / 25 °C

With dmap; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo500143v

upstream raw materials:

glutaric anhydride,

N-(3-aminopropionyl)-5,6-dihydro-11,12-didehydrodibenzo[b,f]azocine

Downstream raw materials:

C₅₃H₅₁N₅O₇

C₅₂H₅₁N₅O₆

C₅₉H₅₈N₈O₆