1255942-06-3 Usage
Description
DBCO-amine is a simple building block containing a DBCO moiety and will add minimal spacer to the modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
Different sources of media describe the Uses of 1255942-06-3 differently. You can refer to the following data:
1. Azadibenzocyclooctyne amine is a carbonyl reactive reagent used to incorporate ADIBO into organic compounds, surfaces or particlesAzadibenzocyclooctyne amine is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.
2. DBCO-Amine was useful for the study of labelled T-cells, which were used to predict the therapeutic efficacy of adoptive T-cell therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 1255942-06-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,5,9,4 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1255942-06:
(9*1)+(8*2)+(7*5)+(6*5)+(5*9)+(4*4)+(3*2)+(2*0)+(1*6)=163
163 % 10 = 3
So 1255942-06-3 is a valid CAS Registry Number.
1255942-06-3Relevant articles and documents
NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF
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Paragraph 1322, (2017/12/29)
Disclosed herein, inter alia, are compounds, compositions, and methods of thereof in the sequencing a nucleic acid.
Surface functionalization using catalyst-free azide-alkyne cycloaddition
Kuzmin, Alexander,Poloukhtine, Andrei,Wolfert, Margreet A.,Popik, Vladimir V.
, p. 2076 - 2085 (2011/07/09)
The utility of catalyst-free azide-alkyne [3 + 2] cycloaddition for the immobilization of a variety of molecules onto a solid surface and microbeads was demonstrated. In this process, the surfaces are derivatized with aza-dibenzocyclooctyne (ADIBO) for the immobilization of azide-tagged substrates via a copper-free click reaction. Alternatively, ADIBO-conjugated molecules are anchored to the azide-derivatized surface. Both immobilization techniques work well in aqueous solutions and show excellent kinetics under ambient conditions. We report an efficient synthesis of aza-dibenzocyclooctyne (ADIBO), thus far the most reactive cyclooctyne in cycloaddition to azides. We also describe convenient methods for the conjugation of ADIBO with a variety of molecules directly or via a PEG linker.
