C₁₈H₂₅NO₅

Base Information

• Chemical Name: C₁₈H₂₅NO₅
• CAS No.: 1310929-14-6
• Molecular Formula: C₁₈H₂₅NO₅
• Molecular Weight: 335.4
• Mol file: 1310929-14-6.mol

Synonyms:C₁₈H₂₅NO₅

Chemical Property of C₁₈H₂₅NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₅NO₅

There total 2 articles about C₁₈H₂₅NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

tert-butyl 2-(3-methoxyphenyl)-2-oxoacetate (1308252-53-0) + N-trimethylsilyl O-tert-butyl carbamate (238096-95-2) → C18H25NO5 (1310929-14-6)

Guidance literature:

N-trimethylsilyl O-tert-butyl carbamate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

tert-butyl 2-(3-methoxyphenyl)-2-oxoacetate; In tetrahydrofuran; hexane; at -78 ℃; for 5h;

With chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

DOI:10.1246/cl.2011.326

Reference yield:

tert-butyl carbazate (4248-19-5) → C18H25NO5 (1310929-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 5 h / -78 °C

2.3: 2 h / -78 - 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1246/cl.2011.326

Reference yield: 80.0%

C18H25NO5 (1310929-14-6) + N-α-diazoacetyloxazolidinone → C23H30N2O8 (1310929-22-6)

Guidance literature:

With (S)-[3,3’-diphenyl-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide; In toluene; at -20 ℃; for 4h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja203901h

upstream raw materials:

tert-butyl 2-(3-methoxyphenyl)-2-oxoacetate

N-trimethylsilyl O-tert-butyl carbamate

tert-butyl carbazate

Downstream raw materials:

C₂₃H₃₀N₂O₈

C₃₀H₄₂N₂O₈S

Refernces