238096-95-2Relevant academic research and scientific papers
Modular Catalytic Synthesis of 3-Amino-3-aryl-2-oxindoles: Rh Catalysis with Isatin-Derived N-Boc-Protected Ketimines
Marques, Carolina S.,Burke, Anthony J.
supporting information, p. 806 - 812 (2017/01/18)
Chiral 3-amino-3-aryloxindoles are important biologically active compounds. Using a catalytic modular approach, 31 new 3-amino-3-aryl-2-oxindoles were prepared by a simple Rh-catalysed addition of arylboronic acids to isatin-derived N-Boc-protected ketimines (Boc = tert-butoxycarbonyl). A low catalyst loading of 3 mol-% was used, and the reaction showed a wide scope with high functional-group compatibility, and gave good yields. We report the first catalytic enantioselective reactions with this substrate. Deprotection of the Boc group was easily accomplished in good yields.
Development of a practical synthetic method for n-tert-butoxycarbonyl α-ketimino esters
Hashimoto, Takuya,Kumiko, Yamamoto,Maruoka, Keiji
supporting information; experimental part, p. 326 - 327 (2011/05/14)
Despite the potential synthetic utility of N-Boc α-ketimino esters as prochiral ketimines to give chiral α-tertiary amines, there has been no general method to access these molecules in a practical fashion. We report herein a procedure for the one-step sy
