2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one

Base Information

Chemical Name:2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one
CAS No.:1257875-20-9
Molecular Formula:C₂₅H₂₇F₄NO₃Si
Molecular Weight:493.573
Hs Code.:

Synonyms:2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one

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Chemical Property of 2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one

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Technology Process of 2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one

There total 11 articles about 2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958457-27-7
6-methyl-2-(O-tert-butyldimethylsilyl)hydroxymethyl-3-trifluoromethanesulfonyloxy-pyran-4(1H)-one

: 1257875-17-4
{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}boronic acid

: 1257875-20-9
2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; toluene; at 80 ℃; for 3h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 958457-27-7
6-methyl-2-(O-tert-butyldimethylsilyl)hydroxymethyl-3-trifluoromethanesulfonyloxy-pyran-4(1H)-one

: 1257875-18-5
2-[2-fluoro-4-(trifluoromethyl)phenyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1257875-20-9
2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1257875-17-4
{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}boronic acid

: 1257875-19-6
2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

: 1257875-20-9
2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}-6-methyl-4H-pyran-4-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01256