2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

Base Information

Chemical Name:2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one
CAS No.:1257875-19-6
Molecular Formula:C₂₅H₂₈F₃NO₄Si
Molecular Weight:491.582
Hs Code.:

Synonyms:2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

There total 8 articles about 2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 958457-27-7
6-methyl-2-(O-tert-butyldimethylsilyl)hydroxymethyl-3-trifluoromethanesulfonyloxy-pyran-4(1H)-one

: 1257875-27-6
(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)boronic acid

: 1257875-19-6
2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01256

Reference yield:

: 1257875-15-2
5-bromo-2-{4-[(trifluoromethyl)oxy]phenyl}pyridine

: 1257875-19-6
2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / toluene; water; ethanol / 3 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; sodium carbonate; In 1,4-dioxane; ethanol; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256

Reference yield:

: 958457-25-5
3-benzyloxy-6-methyl-2-(O-tert-butyldimethylsily l)-hydroxymethyl-pyran-4(1H)-one

: 1257875-19-6
2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-methyl-3-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 1551.49 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / toluene; water; ethanol / 3 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 3: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256