(3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one

Base Information

• Chemical Name: (3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one
• CAS No.: 848302-18-1
• Molecular Formula: C₂₄H₂₆N₂O₃S
• Molecular Weight: 422.548

Synonyms:(3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one

Chemical Property of (3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one

There total 2 articles about (3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one (848302-22-7) + 1,2-bis(trimethylsilyloxy)cyclohex-1-ene (6838-67-1) → (3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one (848302-18-1)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1021/jo0488107

Reference yield: 97.84%

(3S,7S,7aR)-6-benzyl-7-(2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one → (3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one (848302-18-1)

Guidance literature:

With oxygen; sodium hydroxide; sodium sulfite; In ethanol; at 15 ℃; for 6h;

Reference yield: 70.0%

(3S,7R,7aR)-6-benzyl-7-(1-hydroxy-2-oxocyclohexyl)-3-phenyl-tetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one (848302-18-1) → 6-[(3S,7R,7aR)-6-benzyl-5-oxo-3-phenyltetrahydro-1H-imidazo[1,5-c][1,3]thiazol-7-yl]-6-oxohexanoic acid (112878-96-3)

Guidance literature:

With tert.-butylhydroperoxide; potassium hydroxide; In methanol; water; for 0.5h;

DOI:10.1021/jo0488107

upstream raw materials:

(3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one

1,2-bis(trimethylsilyloxy)cyclohex-1-ene

Downstream raw materials:

6-[(3S,7R,7aR)-6-benzyl-5-oxo-3-phenyltetrahydro-1H-imidazo[1,5-c][1,3]thiazol-7-yl]-6-oxohexanoic acid

methyl (5Z)-5-[(3aS,6aR)-1,3-dibenzyl-2-oxohexahydro-4H-thieno[3,4-d]imidazol-4-ylidene]pentanoate

methyl 6-[(3S,7R,7aR)-6-benzyl-5-oxo-3-phenyltetrahydro-5H-imidazo[1,5-c][1,3]thiazol-7-yl]-6-oxohexanoate

biotin

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