848302-22-7Relevant academic research and scientific papers
Synthesis method of d-biotin
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, (2019/04/04)
The invention discloses a synthesis method of d-biotin. The synthesis method comprises the following steps: taking cysteine hydrochloride, benzaldehyde and benzyl isocyanate as starting materials, andsubjecting the starting materials to condensation, cyclization, reduction, condensation, oxidation, reduction, cyclization, elimination, catalytic hydrogenation and debenzylation sequentially to obtain the d-biotin. The method has the advantages that the raw materials are cheap and easy to obtain, the safety is good, the reaction conditions are mild and easy to control, the production cost is lowered, green and environmental protection is achieved, the reaction yield is high, separation is easy, and the purity of the obtained d-biotin is high.
A PROCESS FOR THE PREPARATION OF INTERMEDIATE FOR THE PREPARATION OF OSELTAMIVIR PHOSPHATE
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, (2015/04/22)
The present invention discloses an economic, simple, azide and azindine complexity free process for the synthesis of osletamivir phosphate (Tamiflu) by stereospecific amidoalkylation of imidazothiazolone from easily available L-cysteine via Ramberg- Backlund reaction and Sharpless-Reich protocol.
An unusual stereochemical outcome of radical cyclization: Synthesis of (+)-biotin
Chavan, Subhash P.,Chittiboyina, Amar G.,Ramakrishna, Guduru,Tejwani, Rajkumar B.,Ravindranathan,Kamat, Subhash K.,Rai, Beena,Sivadasan, Latha,Balakrishnan, Kamalam,Ramalingam,Deshpande
, p. 9273 - 9280 (2007/10/03)
An enantioselective synthesis of (+)-biotin 1 starting from naturally available cysteine is described. The key steps are the unusual stereochemical outcome of radical cyclization of compound 10 to prepare 5,5-fused system 11, and the introduction of C4-sidechain at C6 in 13 via a Grignard reaction.
