2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one

Base Information

Chemical Name:2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one
CAS No.:1256476-14-8
Molecular Formula:C₁₉H₁₉F₃N₄O
Molecular Weight:376.381
Hs Code.:

Synonyms:2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one

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Chemical Property of 2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one

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Technology Process of 2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one

There total 1 articles about 2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256476-02-4
6-(tert-butoxycarbonyl)-2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-(3H)-one

: 1256476-14-8
2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one

Guidance literature:: 6-(tert-butoxycarbonyl)-2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-(3H)-one; With trifluoroacetic acid; In dichloromethane; at 20 ℃; Cooling with ice;

With sodium hydroxide; In dichloromethane; water; Cooling with ice;

Reference yield: 67.0%

: 1256476-14-8
2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one

: 122-01-0
4-chloro-benzoyl chloride

: 1256701-54-8
6-(4-chlorobenzoyl)-3-propargyl-2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one hydrochloride

Guidance literature:: 2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one; 4-chloro-benzoyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

With hydrogenchloride; In ethanol; dichloromethane;

Reference yield: 61.0%

: 1256476-14-8
2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 1256701-53-7
6-(4-cyano-2-fluorobenzoyl)-3-propargyl-2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one hydrochloride

Guidance literature:: 4-cyano-2-fluorobenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

2-(S)-{1-[4-(trifluoromethyl)phenyl]ethylamino}-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-(3H)-one; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; In ethanol; dichloromethane;