1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene

Base Information

• Chemical Name: 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene
• CAS No.: 1602486-94-1
• Molecular Formula: C₂₆H₁₇F₉N₂S
• Molecular Weight: 560.486
• Mol file: 1602486-94-1.mol

Synonyms:1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene

Chemical Property of 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene

There total 5 articles about 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2-methyl-3-(perfluorocyclopent-1-en-1-yl)-5-(4-(trifluoromethyl)phenyl)thiophene (1374693-92-1) + 1,2-dimethyl-3-bromine-7-azaindole (1367867-13-7) → 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene (1602486-94-1)

Guidance literature:

1,2-dimethyl-3-bromine-7-azaindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78.16 ℃; for 0.5h; Inert atmosphere;

2-methyl-3-(perfluorocyclopent-1-en-1-yl)-5-(4-(trifluoromethyl)phenyl)thiophene; In tetrahydrofuran; hexane; at -78.16 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.dyepig.2014.03.003

Reference yield:

1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine (143141-23-5) → 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene (1602486-94-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -25.16 °C / Inert atmosphere

1.2: 10 h / 20 - 25 °C / Inert atmosphere

2.1: N-Bromosuccinimide; tetrachloromethane / 12 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -0.16 °C

3.2: 24 h / -0.16 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78.16 °C / Inert atmosphere

4.2: 2 h / -78.16 °C / Inert atmosphere

With tetrachloromethane; N-Bromosuccinimide; n-butyllithium; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1016/j.dyepig.2014.03.003

Reference yield:

1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridine (189089-83-6) → 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene (1602486-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; tetrachloromethane / 12 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -0.16 °C

2.2: 24 h / -0.16 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78.16 °C / Inert atmosphere

3.2: 2 h / -78.16 °C / Inert atmosphere

With tetrachloromethane; N-Bromosuccinimide; n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1016/j.dyepig.2014.03.003

upstream raw materials:

7-Azaindole

1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine

1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridine

3-bromo-2-methyl-1-phenylsulfonylpyrrolo[2,3-b]pyridine