N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

Base Information

Chemical Name:N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine
CAS No.:1427158-37-9
Molecular Formula:C₁₈H₂₀N₄OS
Molecular Weight:340.449
Hs Code.:

N<sup>3</sup>-cyclobutyl-N<sup>7</sup>-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

Synonyms:N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

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Chemical Property of N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

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Technology Process of N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

There total 8 articles about N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2516-34-9
cyclobutylamine

: 1427158-12-0
3-bromo-N-(4-methoxybenzyl)[1,2]thiazolo[4,5-b]pyridin-7-amine

: 1427158-37-9
N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

Guidance literature:: With potassium carbonate; sodium iodide; In dimethyl sulfoxide; at 120 - 130 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1427158-10-8
3-bromo-4-chloropyridine-2-carbonitrile

: 1427158-37-9
N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 70 °C

2: 1-methyl-pyrrolidin-2-one; sodium thiomethoxide / 1 h / 130 - 140 °C

3: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

4: potassium carbonate; sodium iodide / dimethyl sulfoxide / 18 h / 120 - 130 °C / Inert atmosphere

With 1-methyl-pyrrolidin-2-one; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium thiomethoxide; In dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1427158-13-1
4-[(4-methoxybenzyl)amino]-3-sulfanylpyridine-2-carbonitrile

: 1427158-37-9
N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

2: potassium carbonate; sodium iodide / dimethyl sulfoxide / 18 h / 120 - 130 °C / Inert atmosphere

With bromine; potassium carbonate; sodium iodide; In dimethyl sulfoxide; ethyl acetate;