1427158-12-0

Basic information

• Product Name: 3-bromo-N-(4-methoxybenzyl)[1,2]thiazolo[4,5-b]pyridin-7-amine
• Synonyms: 3-bromo-N-(4-methoxybenzyl)[1,2]thiazolo[4,5-b]pyridin-7-amine
• CAS NO: 1427158-12-0
• Molecular Weight: 350.239
• Mol File: 1427158-12-0.mol

Chemical Properties

• CAS DataBase Reference: 3-bromo-N-(4-methoxybenzyl)[1,2]thiazolo[4,5-b]pyridin-7-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-N-(4-methoxybenzyl)[1,2]thiazolo[4,5-b]pyridin-7-amine(1427158-12-0)
• EPA Substance Registry System: 3-bromo-N-(4-methoxybenzyl)[1,2]thiazolo[4,5-b]pyridin-7-amine(1427158-12-0)

Safety Data

• Hazardous Substances Data: 1427158-12-0(Hazardous Substances Data)

Upstream product

• 99839-30-2 3-bromo-4-chloropyridine-1-oxide 
• 1678-49-5 3-Bromo-4-nitropyridine N-oxide 
• 2402-97-3 3-bromopyridine N-oxide 
• 626-55-1 3-Bromopyridine 
• 1427158-13-1 4-[(4-methoxybenzyl)amino]-3-sulfanylpyridine-2-carbonitrile 
• 1427158-11-9 3-bromo-4-[(4-methoxybenzyl)amino]pyridine-2-carbonitrile 
• 1427158-10-8 3-bromo-4-chloropyridine-2-carbonitrile 

Downstream Products

• 1427158-58-4 2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide 
• 1427158-59-5 2-chloro-5-{[(2,2-dimethylpropanoyl)amino]methyl}-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide 
• 1427263-56-6 C₂₁H₁₅ClF₃N₅OS 
• 1427158-60-8 2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide 
• 1427158-09-5 N³-[4-(trifluoromethyl)phenyl][1,2]thiazolo[4,5-b]pyridine-3,7-diamine 
• 1427158-71-1 5-(aminomethyl)-2-chloro-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide hydrochloride 
• 1427158-70-0 (R)-N-(4-chloro-3-((3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)carbamoyl)benzyl)tetrahydrofuran-2-carboxamide 
• 1427158-73-3 2-chloro-5-((2-hydroxy-2-methylpropanamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide 
• 1427158-15-3 tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate 
• 1427158-14-2 N⁷-(4-methoxybenzyl)-N³-[4-(trifluoromethyl)phenyl][1,2]thiazolo[4,5-b]pyridine-3,7-diamine 
• 1427158-37-9 N³-cyclobutyl-N⁷-(4-methoxybenzyl)isothiazolo[4,5-b]pyridine-3,7-diamine 

Relevant articles and documents

SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS

The present invention relates to bicyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (m PGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I)