(E)-4-phenyl-3-pentenoic acid

Base Information

• Chemical Name: (E)-4-phenyl-3-pentenoic acid
• CAS No.: 223243-86-5
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Mol file: 223243-86-5.mol

Synonyms:(E)-4-phenyl-3-pentenoic acid

Chemical Property of (E)-4-phenyl-3-pentenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-phenyl-3-pentenoic acid

There total 9 articles about (E)-4-phenyl-3-pentenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

malonic acid (141-82-2) + 2-Phenylpropanal (34713-70-7) → (E)-4-phenyl-3-pentenoic acid (223243-86-5)

Guidance literature:

malonic acid; 2-Phenylpropanal; With triethylamine; for 2h; Reflux;

With hydrogenchloride; In diethyl ether; water; at 20 ℃; Further stages;

DOI:10.1002/anie.201107802

Reference yield: 45.0%

malonic acid (141-82-2) + 2-Phenylpropanal (34713-70-7) → (E)-4-phenyl-3-pentenoic acid (223243-86-5) + (Z)-4-phenylpent-3-enoic acid (119271-86-2)

Guidance literature:

With triethylamine; Heating;

DOI:10.1002/ejoc.200700041

Reference yield: 40.0%

malonic acid (141-82-2) + 2-Phenylpropanal (34713-70-7) → (E)-4-phenyl-3-pentenoic acid (223243-86-5) + (E)-4-phenyl-2-pentenoic acid (223243-87-6,103986-66-9)

Guidance literature:

With silica gel; for 0.0833333h; Irradiation;

DOI:10.1016/S0040-4039(99)00113-6

upstream raw materials:

malonic acid

2-Phenylpropanal

acetophenone

(2-carboxyethyl)triphenylphosphonium bromide

Downstream raw materials:

ethyl (E)-4-phenyl-3-pentenoate

(Z)-4-phenylpent-3-enoic acid

C₁₁H₁₁BrO₂

(-)-(S)-5-methyl-5-phenylfuran-2(5H)-one

Refernces

• 1、 Ding, Rui,Lan, Liyuan,Li, Shuhui,Liu, Yongguo,Yang, Shaoxiang,Tian, Hongyu,Sun, Baoguo. "A Novel Method for the Chlorolactonization of Alkenoic Acids Using Diphenyl Sulfoxide/Oxalyl Chloride". . p. 2555 - 2566. Retrieved 2018/05/03.
• 2、 Fu, Ming-Chen,Shang, Rui,Cheng, Wan-Min,Fu, Yao. "Efficient Pd-Catalyzed Regio- and Stereoselective Carboxylation of Allylic Alcohols with Formic Acid". . p. 8818 - 8822. Retrieved 2017/07/11.