4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime

Base Information

Chemical Name:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime
CAS No.:1586758-81-7
Molecular Formula:C₁₉H₁₄F₂N₂O₂
Molecular Weight:340.329
Hs Code.:

Synonyms:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime

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Chemical Property of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime

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Technology Process of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime

There total 9 articles about 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1586758-78-2
N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

: 106-96-7
propargyl bromide

: 1586758-81-7
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime

Guidance literature:: N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

propargyl bromide; In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/jf500461a DOI:10.1021/jf500461a

Reference yield: 47.0%

: 1586758-81-7
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 1h;

In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1586758-81-7
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-prop-2-yn-1-yl oxime

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride / ethanol / 8 h / Reflux

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 11.5 h / 0 °C / Reflux

2.2: 5 h / Reflux

3.1: triethylamine / tetrahydrofuran / 7.5 h / 0 - 20 °C

4.1: thionyl chloride / chloroform / 2.83 h / Reflux

5.1: sulfuric acid; chromium(VI) oxide; acetic acid / 6 h

6.1: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

7.2: 2 h

With chromium(VI) oxide; sodium tetrahydroborate; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; iodine; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jf500461a