(E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester

Base Information

• Chemical Name: (E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester
• CAS No.: 154261-02-6
• Molecular Formula: C₁₉H₂₅NO₄
• Molecular Weight: 331.412
• Mol file: 154261-02-6.mol

Synonyms:(E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester

Chemical Property of (E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester

There total 1 articles about (E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(E)-3-phenyl-2-propenyl]diethylamine (38282-01-8) + dimethyl acetylenedicarboxylate (762-42-5) → (E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester (154261-02-6)

Guidance literature:

With toluene-4-sulfonic acid; In chloroform-d1; at 20 ℃;

DOI:10.1021/ja00081a019

Reference yield:

(E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester (154261-02-6) → 2-Oxo-3-(1-phenyl-allyl)-succinic acid dimethyl ester

Guidance literature:

With sulfuric acid; In chloroform; at 20 ℃; for 36h; Yield given;

DOI:10.1021/ja00081a019

Reference yield:

(E)-2-Diethylamino-3-(1-phenyl-allyl)-but-2-enedioic acid dimethyl ester (154261-02-6) → methyl 3-phenyl-4-pentenoate (90172-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 M aq. H₂SO₄ / CHCl₃ / 36 h / 20 °C

2: 5 M aq. NaOH / diethyl ether / 24 h / 23 °C

With sodium hydroxide; sulfuric acid; In diethyl ether; chloroform;

DOI:10.1021/ja00081a019

upstream raw materials:

N-[(E)-3-phenyl-2-propenyl]diethylamine

dimethyl acetylenedicarboxylate

Downstream raw materials:

3-phenylpent-4-enoic acid

methyl 3-phenyl-4-pentenoate