7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Base Information

Chemical Name:7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine
CAS No.:1339891-28-9
Molecular Formula:C₂₁H₂₄BrN₅OSi
Molecular Weight:470.444
Hs Code.:

Synonyms:7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

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Chemical Property of 7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

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Technology Process of 7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

There total 8 articles about 7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.77%

: 894807-98-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazole

: 1339891-35-8
7-(4-bromophenyl)-5-chloroimidazo[1,2-c]pyrimidine

: 1339891-28-9
7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Guidance literature:: With water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 70 ℃; for 7h; glass bomb; Inert atmosphere;

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 1339891-28-9
7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: 0 °C

2.1: ethanol; sodium / copper(II) sulfate / 60 h / Reflux

2.2: pH 7

3.1: sodium hydrogencarbonate / water; dimethyl sulfoxide / 20 °C

4.1: water; tetrahydrofuran / 24 h / Reflux

4.2: 0.17 h / 20 °C

5.1: potassium hydroxide; water / methanol / 4 h / Reflux

5.2: pH 5

6.1: N,N-diethylaniline; trichlorophosphate / acetonitrile / 50 °C

7.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 7 h / 70 °C / glass bomb; Inert atmosphere

With ethanol; water; sodium; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) sulfate; In tetrahydrofuran; methanol; hexanes; 1,2-dimethoxyethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1339891-28-9
7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.53 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 7 h / 70 °C / glass bomb; Inert atmosphere

With water; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;