7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Base Information

Chemical Name:7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine
CAS No.:1339891-90-5
Molecular Formula:C₂₅H₂₉N₇OSi
Molecular Weight:471.637
Hs Code.:

Synonyms:7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

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Chemical Property of 7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

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Technology Process of 7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

There total 10 articles about 7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.9%

: 1339891-28-9
7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1339891-90-5
7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Guidance literature:: With potassium phosphate; water; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In isopropyl alcohol; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 894807-98-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazole

: 1339891-90-5
7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 7 h / 70 °C / glass bomb; Inert atmosphere

2: potassium phosphate; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / isopropyl alcohol / 4 h / 100 °C / Inert atmosphere

With potassium phosphate; water; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In 1,2-dimethoxyethane; isopropyl alcohol;

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 1339891-90-5
7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: 0 °C

2.1: ethanol; sodium / copper(II) sulfate / 60 h / Reflux

2.2: pH 7

3.1: sodium hydrogencarbonate / water; dimethyl sulfoxide / 20 °C

4.1: water; tetrahydrofuran / 24 h / Reflux

4.2: 0.17 h / 20 °C

5.1: potassium hydroxide; water / methanol / 4 h / Reflux

5.2: pH 5

6.1: N,N-diethylaniline; trichlorophosphate / acetonitrile / 50 °C

7.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 7 h / 70 °C / glass bomb; Inert atmosphere

8.1: potassium phosphate; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / isopropyl alcohol / 4 h / 100 °C / Inert atmosphere

With potassium phosphate; ethanol; water; sodium; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) sulfate; XPhos; In tetrahydrofuran; methanol; hexanes; 1,2-dimethoxyethane; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;