methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate

Base Information

Chemical Name:methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate
CAS No.:1599529-79-9
Molecular Formula:C₂₀H₁₅ClF₃NO₃
Molecular Weight:409.792
Hs Code.:

Synonyms:methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate

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Chemical Property of methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate

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Technology Process of methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate

There total 5 articles about methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 1599529-50-6
6-bromo-4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline

: 74-88-4
methyl iodide

: 1599529-79-9
methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate

Guidance literature:: 6-bromo-4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.0166667h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; hexane; at 20 ℃; for 0.0833333h; Sealed tube; Inert atmosphere;

methyl iodide; Further stages;

Reference yield:

: C₁₉H₁₃ClF₃NO₃

: 74-88-4
methyl iodide

: 1599529-79-9
methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate

Guidance literature:: C₁₉H₁₃ClF₃NO₃; methyl iodide; In dimethyl sulfoxide; at 0 - 20 ℃; for 0.0833333h;

With lithium carbonate; In dimethyl sulfoxide; at 40 ℃; for 0.5h;

Reference yield:

: 923977-13-3
2,2-dimethyl-5-(4-trifluoromethyl-benzyl)-[1,3]dioxane-4,6-dione

: 1599529-79-9
methyl 4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / water / 3.66 h / 70 - 78 °C

2.1: trichlorophosphate / 6.66 h / 100 - 110 °C

3.1: toluene / 118 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -70 °C / Inert atmosphere

4.2: 0.08 h / 20 °C / Sealed tube; Inert atmosphere

With n-butyllithium; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; hexane; water; toluene;