methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

Base Information

Chemical Name:methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate
CAS No.:1328885-00-2
Molecular Formula:C₂₈H₄₄F₃NO₄Si
Molecular Weight:543.742
Hs Code.:

Synonyms:methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

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Chemical Property of methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

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Technology Process of methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

There total 4 articles about methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1328884-98-5
3-isopropyl-3-(methoxycarbonyl)hex-5-enoic acid

: (5-(trifluoromethyl)-2-(triisopropylsilyloxy)phenyl)methanamine hydrochloride

: 1328885-00-2
methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

Guidance literature:: 3-isopropyl-3-(methoxycarbonyl)hex-5-enoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

(5-(trifluoromethyl)-2-(triisopropylsilyloxy)phenyl)methanamine hydrochloride; In tetrahydrofuran; for 3h;

Reference yield:

: 556-24-1
methyl 3-methylbutanoate

: 1328885-00-2
methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -15 °C

1.2: 3 h / -78 - -70 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -50 °C

2.2: 1 h / -78 - 0 °C

3.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4.2: 3 h

With n-butyllithium; chloroformic acid ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 72143-24-9
methyl 2-isopropylpent-4-enoate

: 1328885-00-2
methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -50 °C

1.2: 1 h / -78 - 0 °C

2.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 3 h

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;