3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione

Base Information

Chemical Name:3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione
CAS No.:1328885-01-3
Molecular Formula:C₂₇H₄₀F₃NO₃Si
Molecular Weight:511.7
Hs Code.:

Synonyms:3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione

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Chemical Property of 3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione

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Technology Process of 3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione

There total 5 articles about 3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1328885-00-2
methyl 2-isopropyl-2-(2-oxo-2-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzylamino)ethyl)pent-4-enoate

: 1328885-01-3
3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione

Guidance literature:: With sodium methylate; In methanol; at 0 ℃; for 12h;

Reference yield:

: 1328884-99-6
C₁₅H₂₆O₄

: 1328885-01-3
3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h

3.1: sodium methylate / methanol / 12 h / 0 °C

With sodium methylate; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 556-24-1
methyl 3-methylbutanoate

: 1328885-01-3
3-allyl-3-isopropyl-1-(5-(trifluoromethyl)-2-(triisopropylsilyloxy)benzyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -15 °C

1.2: 3 h / -78 - -70 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -50 °C

2.2: 1 h / -78 - 0 °C

3.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4.2: 3 h

5.1: sodium methylate / methanol / 12 h / 0 °C

With n-butyllithium; sodium methylate; chloroformic acid ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane;