3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide

Base Information

Chemical Name:3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide
CAS No.:216581-56-5
Molecular Formula:C₁₆H₁₇NO₅
Molecular Weight:303.315
Hs Code.:

Synonyms:3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide

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Chemical Property of 3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide

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Technology Process of 3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide

There total 8 articles about 3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-43-5
ethanolamine

: 216581-49-6
N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

: 216581-56-5
3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide

Guidance literature:: In dichloromethane;
DOI:10.1016/S0968-0896(00)00273-X

Reference yield:

: 644-46-2
allomaltol

: 216581-56-5
3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / aq. NaOH / 12 h / 25 °C

2: 80 percent / aq. NaOH / methanol / 12 h / Heating

3: 87.7 percent / Et₃N; SO₃*pyridine / CHCl₃; dimethylsulfoxide / 12 h / 25 °C

4: 85 percent / NaClO₂; NH₂SO₃H / acetone; H₂O / 1 h / 25 °C

5: 71 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 25 °C

6: 90 percent / CH₂Cl₂

With dmap; sodium hydroxide; sodium chlorite; pyridine-SO₃ complex; aminosulfonic acid; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0968-0896(00)00273-X

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 216581-56-5
3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carboxy-(N-2'-hydroxyethyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1: 75.9 percent / SOCl₂ / 1 h / 25 °C

2: 62.8 percent / Zn; conc. HCl / H₂O / 70 - 80 °C

3: 82 percent / aq. NaOH / 12 h / 25 °C

4: 80 percent / aq. NaOH / methanol / 12 h / Heating

5: 87.7 percent / Et₃N; SO₃*pyridine / CHCl₃; dimethylsulfoxide / 12 h / 25 °C

6: 85 percent / NaClO₂; NH₂SO₃H / acetone; H₂O / 1 h / 25 °C

7: 71 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 25 °C

8: 90 percent / CH₂Cl₂

With hydrogenchloride; dmap; sodium hydroxide; sodium chlorite; thionyl chloride; pyridine-SO₃ complex; aminosulfonic acid; triethylamine; dicyclohexyl-carbodiimide; zinc; In methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0968-0896(00)00273-X