methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Base Information

Chemical Name:methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
CAS No.:934621-67-7
Molecular Formula:C₁₅H₁₂N₂O₅S
Molecular Weight:332.337
Hs Code.:

Synonyms:methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

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Chemical Property of methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

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Technology Process of methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

There total 5 articles about methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 934621-66-6
ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

: 934621-67-7
methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm200208d

Reference yield:

: 936-12-9
2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 934621-67-7
methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 0.75 h

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide / -20 - -10 °C

4: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

With N-Bromosuccinimide; tetrabutylammomium bromide; sodium hydride; sodium hydroxide; lithium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200208d

Reference yield:

: 881674-85-7
ethyl 2-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

: 934621-67-7
methyl 4-hydroxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / -20 - -10 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

With N-Bromosuccinimide; sodium hydride; lithium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200208d