ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate
CAS No.:934621-66-6
Molecular Formula:C₂₄H₂₆N₂O₈S₂
Molecular Weight:534.611
Hs Code.:

Synonyms:ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

There total 4 articles about ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 934621-65-5
ethyl 2-(bromomethyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

: 2645-02-5
methyl tosylglycinate

: 934621-66-6
ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at -20 - -10 ℃;
DOI:10.1021/jm200208d

Reference yield:

: 936-12-9
2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 934621-66-6
ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 0.75 h

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide / -20 - -10 °C

With N-Bromosuccinimide; tetrabutylammomium bromide; sodium hydride; sodium hydroxide; dibenzoyl peroxide; In tetrachloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200208d

Reference yield:

: 881674-85-7
ethyl 2-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

: 934621-66-6
ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / -20 - -10 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200208d