tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate

Base Information

Chemical Name:tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate
CAS No.:1166827-62-8
Molecular Formula:C₂₂H₃₄BNO₅
Molecular Weight:403.327
Hs Code.:

Synonyms:tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate

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Chemical Property of tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate

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Technology Process of tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate

There total 4 articles about tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1166827-63-9
tert-butyl cis-4-[(bromopyridin-2-yl)oxy]cyclohexanecarboxylate

: 73183-34-3
bis(pinacol)diborane

: 1166827-62-8
tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 85 ℃; for 16h;

Reference yield:

: 3685-26-5,17419-81-7,3685-22-1
cis-4-hydroxycyclohexanecarboxylic acid

: 1166827-62-8
tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / ISOPROPYLAMIDE / 0.17 h / 0 °C

1.2: 2.5 h / 100 °C

2.1: 0.75 h / 120 °C / Microwave irradiation

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 85 °C

With potassium acetate; sodium hydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ISOPROPYLAMIDE;

Reference yield:

: 766-11-0
5-bromo-2-fluoropyridine

: 1166827-62-8
tert-butyl cis-4-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / ISOPROPYLAMIDE / 0.17 h / 0 °C

1.2: 2.5 h / 100 °C

2.1: 0.75 h / 120 °C / Microwave irradiation

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 85 °C

With potassium acetate; sodium hydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ISOPROPYLAMIDE;