5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Base Information

Chemical Name:5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline
CAS No.:1093101-59-7
Molecular Formula:C₂₈H₂₁ClN₆O₂
Molecular Weight:508.967
Hs Code.:

Synonyms:5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

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Chemical Property of 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Chemical Property:

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Technology Process of 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

There total 12 articles about 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093101-58-6
5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one

: 1093101-59-7
5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Guidance literature:: With trichlorophosphate; at 100 ℃; for 1h;

Reference yield:

: 42398-73-2,34528-67-1
6-methylisoquinoline

: 1093101-59-7
5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C

3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C

4: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

6: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

7: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

8: trichlorophosphate / 1 h / 100 °C

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; potassium nitrate; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;

Reference yield:

: 188121-31-5
6-methyl-5-nitroisoquinoline

: 1093101-59-7
5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C

3: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

4: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

5: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

6: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

7: trichlorophosphate / 1 h / 100 °C

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;