5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Base Information

• Chemical Name: 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline
• CAS No.: 1093101-59-7
• Molecular Formula: C₂₈H₂₁ClN₆O₂
• Molecular Weight: 508.967
• Mol file: 1093101-59-7.mol

Synonyms:5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Chemical Property of 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

There total 12 articles about 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one (1093101-58-6) → 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline (1093101-59-7)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 1h;

Reference yield:

6-methylisoquinoline (42398-73-2,34528-67-1) → 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline (1093101-59-7)

Guidance literature:

Multi-step reaction with 8 steps

1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C

3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C

4: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

6: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

7: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

8: trichlorophosphate / 1 h / 100 °C

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; potassium nitrate; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;

Reference yield:

6-methyl-5-nitroisoquinoline (188121-31-5) → 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline (1093101-59-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C

3: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

4: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

5: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

6: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

7: trichlorophosphate / 1 h / 100 °C

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;

upstream raw materials:

5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one

6-methyl-5-nitroisoquinoline

6-methylisoquinoline

1-chloro-6-methyl-5-nitroisoquinoline

Downstream raw materials:

5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine