5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one

Base Information

• Chemical Name: 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one
• CAS No.: 1093101-58-6
• Molecular Formula: C₂₈H₂₂N₆O₃
• Molecular Weight: 490.521
• Mol file: 1093101-58-6.mol

Synonyms:5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one

Chemical Property of 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one

There total 11 articles about 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

5-hydroxy-6-methylisoquinolin-1(2H)-one (943606-93-7) + 9-(4-methoxybenzyl)-6-(2-fluoropyridin-3-yl)-9H-purine (1093101-54-2) → 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one (1093101-58-6)

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 1h; microwave;

Reference yield:

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one (1093101-58-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

3: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

4: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; acetic acid;

Reference yield:

6-methylisoquinoline (42398-73-2,34528-67-1) → 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one (1093101-58-6)

Guidance literature:

Multi-step reaction with 7 steps

1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C

3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C

4: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

6: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

7: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; potassium nitrate; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;

upstream raw materials:

5-hydroxy-6-methylisoquinolin-1(2H)-one

9-(4-methoxybenzyl)-6-(2-fluoropyridin-3-yl)-9H-purine

6-methyl-5-nitroisoquinoline

6-methylisoquinoline

Downstream raw materials:

5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline

5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine