140645-23-4

Usage

Uses

Used in Medicinal Chemistry:
(R)-N-Boc-3-aminomethylpiperidine is used as a synthetic intermediate for the development of novel drug candidates, leveraging its protected amine group and piperidine ring structure to create biologically active compounds.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-N-Boc-3-aminomethylpiperidine is employed as a building block for the creation of complex organic molecules, taking advantage of its reactive amine group and the Boc protecting group to facilitate selective reactions and the formation of desired products.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-6-4-5-9(7-12)8-13/h9H,4-8,12H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 37675-18-6 (S)-(+)-nipecotic acid ethyl ester 
• 191599-51-6 ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate 
• 191092-08-7 tert-butyl (3S)-3-[[(4-methylbenzenesulfonyl)oxy]methyl]piperidine-1-carboxylate 
• 4606-65-9 (S)-(hydroxymethyl)piperidine 
• 364356-44-5 (S)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 140645-22-3 (3S)-3-azidomethyl-1-(tert-butoxycarbonyl)-piperidine 

Downstream Products

• 879275-35-1 (R)-<<(benzyloxycarbonyl)amino>methyl>piperidine-1-carboxylic acid tert-butyl ester 
• 323183-40-0 N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide 
• 1028280-87-6 (R)-3-[(2-{[(S)-1-(3,3,3-Triphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-acetylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1026269-96-4 3-({3-[4-(3,3,3-triphenyl-propionylamino)-butyrylamino]-propionylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1026352-31-7 (R)-3-[(3-{[(S)-1-(3,3,3-Triphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-propionylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 323183-51-3 (2R)-N-({(3R)-1-(tert-butoxycarbonyl)-3-piperidyl)methyl)-1-{(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}-carbonylpyrrolidine-2-carboxamide 
• 847831-93-0 3-{3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureidomethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 847831-95-2 3-{3-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-ureidomethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 875269-73-1 tert-butyl (3R)-3-{[(2-amino-5-bromobenzoyl)amino]methyl}piperidine-1-carboxylate 
• 847831-98-5 1-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-3-piperidin-3-ylmethyl-urea 
• 697224-71-8 1-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-3-piperidin-3-ylmethyl-urea 

Relevant academic research and scientific papers

Novel Triazolopyrazine Derivatives and Use Thereof

The present invention relates to novel triazolopyrazine derivatives or a pharmaceutically acceptable salt, and a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating hyperproliferative disorders, containing the same as active ingredients. The present invention effectively inhibits c-Met tyrosine kinase activity, thereby being able to be useful as a drug for various hyperproliferative disorders such as cancers, psoriasis, rheumatoid arthritis, diabetic retinitis, etc. related to excessive cell proliferation and growth by abnormal kinase activation.

NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF

The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.

NOVEL AMIDE DERIVATIVES

This invention relates to compounds which are represented by the general formula [I] ???[in which A stands for a group of the following formula [ao] or [b0] ???Ar1, Ar2 and Ar3 stand for optionally substituted phenyl; k stands for 0 or 1; m, n and s stand for 0, 1 or 2; R1 stands for hydrogen or optionally substituted lower alkyl; R2, R3, R4 and R5 either stand for hydrogen or optionally substituted lower alkyl, or R2 and R3, or R4 and R5 together stand for trimethylene and the like; R60 stands for hydrogen, alkyl, or the like; R61and R71 either stand for alkyl and the like, or together stand for trimethylene and the like; X stands for carbonyl or methylene; Y stands for nitrogen or methine; and Q- stands for anion], and the like. The compounds of the invention exhibit selective antagonism to muscarinic M3 receptors, and therefore are useful as safe and effective agents showing little side effect, for treating diseases of the respiratory, urinary and digestive systems.

Sulfonamidocarboxamides

Sulfonamidocarboxamides of the formula STR1 wherein A, M, Q, X and Y have the significance given in the description, as well as hydrates, solvates and salts thereof, which inhibit thrombin-induced blood platelet aggregation and clotting of fibrinogen in plasma, as described. The compounds of formula I can be prepared by amidination of a cyclic amino group standing for grouping X or by C(O)N(Q) amide formation.

Design and synthesis of potent and highly selective thrombin inhibitors

Thrombin, a serine protease, plays a central role in the initiation and propagation of thrombotic events. An extensive search for new thrombin inhibitors was performed, using an unconventional approach. Screening of small basic molecules for binding in th

Guanidine derivatives compositions and use

Compounds of the formula STR1 wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.