N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

Base Information

• Chemical Name: N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide
• CAS No.: 925673-27-4
• Molecular Formula: C₃₇H₅₁NO₃
• Molecular Weight: 557.817
• Mol file: 925673-27-4.mol

Synonyms:N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

Chemical Property of N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

There total 10 articles about N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-((6R,8R,9S,13S,14S)-3-Hydroxy-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-yl)-heptanoic acid butyl-methyl-amide (925673-14-9) + benzyl bromide (100-39-0) → N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide (925673-27-4)

Guidance literature:

With caesium carbonate; In acetonitrile; for 2.5h; Heating;

DOI:10.1016/j.bmc.2006.10.055

Reference yield:

7-(3,17β-dihydroxyestra-1,3,5(10),6(7)-teraen-6-yl)heptanol (925673-19-4) → N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide (925673-27-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: H₂ / Pd-C / ethyl acetate / 4.5 h / 20 °C

2.1: Jones' reagent / acetone / 0.33 h / 20 °C

3.1: tributylamine / CH₂Cl₂ / 0.67 h / -10 °C

3.2: 50 percent / CH₂Cl₂ / 3 h / 20 °C

4.1: 96 percent / K₂CO₃ / methanol; H₂O / 3 h / 20 °C

5.1: 100 percent / cesium carbonate / acetonitrile / 2.5 h / Heating

With jones' reagent; tributyl-amine; hydrogen; potassium carbonate; caesium carbonate; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate; acetone; acetonitrile;

DOI:10.1016/j.bmc.2006.10.055

Reference yield:

3,17β-bis(tetrahydro-2H-pyran-2-yloxy)-6-[7-(tetrahydro-2H-pyran-2-yloxy)heptyl]estra-1,3,5(10)-trien-6-ol (925893-08-9) → N-butyl-N-methyl-7-(3-benzyloxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide (925673-27-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 72 percent / hydrochloric acid / ethanol / 1 h / Heating

2.1: H₂ / Pd-C / ethyl acetate / 4.5 h / 20 °C

3.1: Jones' reagent / acetone / 0.33 h / 20 °C

4.1: tributylamine / CH₂Cl₂ / 0.67 h / -10 °C

4.2: 50 percent / CH₂Cl₂ / 3 h / 20 °C

5.1: 96 percent / K₂CO₃ / methanol; H₂O / 3 h / 20 °C

6.1: 100 percent / cesium carbonate / acetonitrile / 2.5 h / Heating

With hydrogenchloride; jones' reagent; tributyl-amine; hydrogen; potassium carbonate; caesium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; ethyl acetate; acetone; acetonitrile;

DOI:10.1016/j.bmc.2006.10.055

upstream raw materials:

7-((6R,8R,9S,13S,14S)-3-Hydroxy-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-yl)-heptanoic acid butyl-methyl-amide

benzyl bromide

7-(3,17β-dihydroxyestra-1,3,5(10),6(7)-teraen-6-yl)heptanol

7-(3,17β-dihydroxyestra-1,3,5(10)-trien-6β-yl)heptanol

Downstream raw materials:

N-butyl-N-methyl-7-(3-benzyloxy-17β-hydroxy-2-methoxyestra-1,3,5(10)-trien-6β-yl)heptanamide

N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

N-butyl-N-methyl-7-(3-benzyloxy-2-iodo-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide