(4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

Base Information

Chemical Name:(4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone
CAS No.:1269605-71-1
Molecular Formula:C₂₄H₂₆FN₅O
Molecular Weight:419.502
Hs Code.:

Synonyms:(4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

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Chemical Property of (4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

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Technology Process of (4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

There total 3 articles about (4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 3731-51-9
2-(Aminomethyl)pyridine

: 1269606-64-5
{4-[2-(4-Fluoro-phenyl)-2-hydroxy-ethyl]-piperazin-1-yl}-pyridin-2-yl-methanone

: 124-63-0
methanesulfonyl chloride

: 1269605-71-1
(4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

Guidance literature:: With triethanolamine; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 389628-28-8
tert-butyl 4-picolinoylpiperazine-1-carboxylate

: 1269605-71-1
(4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid

3: triethanolamine / ethyl acetate; water; tetrahydrofuran

With triethanolamine; trifluoroacetic acid; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 39639-98-0
piperazin-1-yl(pyridin-2-yl)methanone

: 1269605-71-1
(4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

2: triethanolamine / ethyl acetate; water; tetrahydrofuran

With triethanolamine; In tetrahydrofuran; water; ethyl acetate;