2-bromo-5-(tert-butyl)-1,3-diiodobenzene

Base Information

• Chemical Name: 2-bromo-5-(tert-butyl)-1,3-diiodobenzene
• CAS No.: 1104253-51-1
• Molecular Formula: C₁₀H₁₁BrI₂
• Molecular Weight: 464.91
• Mol file: 1104253-51-1.mol

Synonyms:2-bromo-5-(tert-butyl)-1,3-diiodobenzene

Chemical Property of 2-bromo-5-(tert-butyl)-1,3-diiodobenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-5-(tert-butyl)-1,3-diiodobenzene

There total 3 articles about 2-bromo-5-(tert-butyl)-1,3-diiodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-(tert-butyl)-2,5-diiodoaniline (173282-39-8) → 2-bromo-5-(tert-butyl)-1,3-diiodobenzene (1104253-51-1)

Guidance literature:

With hydrogen bromide; copper(I) bromide; sodium nitrite; In water; acetonitrile; at 0 - 50 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.202103188

Reference yield: 71.0%

1-bromo-4-tert-butylbenzene (3972-65-4) → 2-bromo-5-(tert-butyl)-1,3-diiodobenzene (1104253-51-1)

Guidance literature:

With sulfuric acid; periodic acid; potassium iodide; at -30 - -20 ℃; for 24h;

DOI:10.3987/COM-08-S(N)125

Reference yield:

4-tert-Butylaniline (769-92-6) → 2-bromo-5-(tert-butyl)-1,3-diiodobenzene (1104253-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silver sulfate; iodine / 1 h / 20 °C

2.1: sodium nitrite; hydrogen bromide / 0 °C

2.2: 50 °C

With hydrogen bromide; iodine; silver sulfate; sodium nitrite;

DOI:10.1002/anie.201604741

upstream raw materials:

1-bromo-4-tert-butylbenzene

4-tert-Butylaniline

4-(tert-butyl)-2,5-diiodoaniline

Downstream raw materials:

1-bromo-2-iodo-6-(2-pyridyl)-4-tert-butylbenzene