2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester
CAS No.:161468-73-1
Molecular Formula:C₂₀H₁₉F₃N₂O₃
Molecular Weight:392.378
Hs Code.:

Synonyms:2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

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Technology Process of 2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

There total 3 articles about 2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 100-39-0
benzyl bromide

: 161468-47-9
2,3-Dihydro-2-oxo-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

: 161468-73-1
2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; Heating;
DOI:10.1021/jo00111a014

Reference yield:

: 133687-93-1
5-(trifluoromethyl)-1,3-dihydro-2H-benzoimidazol-2-one

: 161468-73-1
2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / NaH / dimethylformamide / 1.) r.t., 75 min, 2.) r.t., 24 h

2: 100 percent / K₂CO₃ / acetonitrile / Heating

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00111a014

Reference yield:

: 368-71-8
4-(trifluoromethyl)-1,2-phenylenediamine

: 161468-73-1
2,3-Dihydro-2-oxo-3-(phenylmethyl)-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent

2: 55 percent / NaH / dimethylformamide / 1.) r.t., 75 min, 2.) r.t., 24 h

3: 100 percent / K₂CO₃ / acetonitrile / Heating

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00111a014