2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide

Base Information

Chemical Name:2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide
CAS No.:1584648-41-8
Molecular Formula:C₁₆H₂₈N₂O₃Si
Molecular Weight:324.495
Hs Code.:

Synonyms:2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide

Chemical Property:

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Technology Process of 2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide

There total 5 articles about 2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1584648-40-7
3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

: 1584648-41-8
2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 1.5h;

Reference yield:

: 1355966-32-3
3-(bromomethyl)-N-methoxy-N-methyl-2-nitrobenzamide

: 1584648-41-8
2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: calcium carbonate / water; 1,4-dioxane / 5 h / Reflux

2: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; calcium carbonate; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 5437-38-7
3-methyl-2-nitrobenzoic acid

: 1584648-41-8
2-amino-3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

1.2: 0.5 h / 0 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4.5 h / 80 °C

3.1: calcium carbonate / water; 1,4-dioxane / 5 h / Reflux

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h

With 1H-imidazole; N-Bromosuccinimide; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; calcium carbonate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;