3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

Base Information

Chemical Name:3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide
CAS No.:1584648-40-7
Molecular Formula:C₁₆H₂₆N₂O₅Si
Molecular Weight:354.478
Hs Code.:

Synonyms:3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

Chemical Property:

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Technology Process of 3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

There total 4 articles about 3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1584648-39-4
3-(hydroxymethyl)-N-methoxy-N-methyl-2-nitrobenzamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1584648-40-7
3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 5437-38-7
3-methyl-2-nitrobenzoic acid

: 1584648-40-7
3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

1.2: 0.5 h / 0 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4.5 h / 80 °C

3.1: calcium carbonate / water; 1,4-dioxane / 5 h / Reflux

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; oxalyl dichloride; N,N-dimethyl-formamide; calcium carbonate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1355966-30-1
N-methoxy-N,3-dimethyl-2-nitrobenzamide

: 1584648-40-7
3-(((tert-butyldimethylsilyl)oxy)methyl)-N-methoxy-N-methyl-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4.5 h / 80 °C

2: calcium carbonate / water; 1,4-dioxane / 5 h / Reflux

3: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; calcium carbonate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; water; N,N-dimethyl-formamide;