6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester

Base Information

• Chemical Name: 6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester
• CAS No.: 198065-12-2
• Molecular Formula: C₂₀H₃₃NO₅Si
• Molecular Weight: 395.571
• Mol file: 198065-12-2.mol

Synonyms:6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester

Chemical Property of 6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester

There total 3 articles about 6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 6-Hydroxy-6-(2-nitro-phenyl)-hexanoic acid ethyl ester (198065-02-0) → 6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester (198065-12-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(97)10084-3

Reference yield:

ethyl 5-bromovalerate (14660-52-7) → 6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester (198065-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) ZnI₂, naphthalene, Li; 2.) Zn, BF₃*OEt₂ / 1.) THF, 16 h; 2.) THF

2: 97 percent / imidazole / dimethylformamide

With 1H-imidazole; naphthalene; boron trifluoride diethyl etherate; lithium; zinc(II) iodide; zinc; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(97)10084-3

Reference yield:

2-nitro-benzaldehyde (552-89-6) → 6-(tert-Butyl-dimethyl-silanyloxy)-6-(2-nitro-phenyl)-hexanoic acid ethyl ester (198065-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) ZnI₂, naphthalene, Li; 2.) Zn, BF₃*OEt₂ / 1.) THF, 16 h; 2.) THF

2: 97 percent / imidazole / dimethylformamide

With 1H-imidazole; naphthalene; boron trifluoride diethyl etherate; lithium; zinc(II) iodide; zinc; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(97)10084-3

upstream raw materials:

tert-butyldimethylsilyl chloride

6-Hydroxy-6-(2-nitro-phenyl)-hexanoic acid ethyl ester

ethyl 5-bromovalerate

2-nitro-benzaldehyde