3-bromo-5-hydroxybenzyl alcohol

Base Information

• Chemical Name: 3-bromo-5-hydroxybenzyl alcohol
• CAS No.: 1020336-51-9
• Molecular Formula: C₇H₇BrO₂
• Molecular Weight: 203.035
• Mol file: 1020336-51-9.mol

Synonyms:3-bromo-5-hydroxybenzyl alcohol

Chemical Property of 3-bromo-5-hydroxybenzyl alcohol

Chemical Property:

• Boiling Point: 348.4±27.0 °C(Predicted)
• PKA: 8.78±0.10(Predicted)
• Density: 1.722±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-hydroxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-5-hydroxybenzyl Alcohol is an intermediate used to prepare (isoxazolylphenyl)arylmethanols as inhibitors of the BET bromodomain family member BRD4(1) for potential use as antitumor agents.

Technology Process of 3-bromo-5-hydroxybenzyl alcohol

There total 1 articles about 3-bromo-5-hydroxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-bromo-5-hydroxy-benzoic acid (140472-69-1) → 3-bromo-5-hydroxybenzyl alcohol (1020336-51-9)

Guidance literature:

With diborane; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2018.05.003

Reference yield: 99.0%

3-bromo-5-hydroxybenzyl alcohol (1020336-51-9) + 4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester (1123157-63-0) → 4-[3-[6-(3-bromo-5-hydroxymethyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (1246206-29-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 - 70 ℃;

Reference yield: 76.0%

3-bromo-5-hydroxybenzyl alcohol (1020336-51-9) + t-butyldimethylsiyl triflate (69739-34-0) → C19H35BrO2Si2

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/acs.orglett.0c03990

upstream raw materials:

3-bromo-5-hydroxy-benzoic acid

Downstream raw materials:

(3-bromo-5-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)methanol

(3-bromo-5-(4-(trifluoromethyl)benzyloxy)phenyl)methanol

4-[3-[6-(3-bromo-5-hydroxymethyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester

3-(3,5-dimethylisoxazol-4-yl)-5-hydroxybenzaldehyde