N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Base Information

Chemical Name:N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide
CAS No.:1356035-27-2
Molecular Formula:C₃₄H₂₈N₈O₃S
Molecular Weight:628.714
Hs Code.:

Synonyms:N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

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Chemical Property of N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

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Technology Process of N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

There total 3 articles about N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1086063-47-9
N-(5-bromo-2-methoxypyridin-3-yl)benzenesulphonamide

: 1356035-53-4
(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)boronic acid

: 1356035-27-2
N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 111 ℃; for 0.133333h; Microwave irradiation;

Reference yield:

: 1356035-54-5
N-(8-bromo-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-ylidene)cyanamide

: 1356035-27-2
N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; bis(pinacol)diborane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.13 h / 111 °C / Microwave irradiation

With potassium acetate; sodium carbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 884495-39-0
5-bromo-2-(methyloxy)-3-pyridinamine

: 98-09-9
benzenesulfonyl chloride

: 1356035-27-2
N-(5-(2-(cyanoimino)-1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 2 h / 0 - 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.13 h / 111 °C / Microwave irradiation

With pyridine; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide;